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A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission, Nat Cell Biol, 28 Jun 2021

宣布时候:2021年06月28日

Nature Cell Biology, 28 June, 2021, DOI:

A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission

Bo Gong, Yuting Guo, Shihui Ding, Xiaohui Liu, Anming Meng, Dong Li & Shunji Jia

Abstract

Endosome fission is essential for cargo sorting and targeting in the endosomal system. However, whether organelles other than the endoplasmic reticulum (ER) participate in endosome fission through membrane contacts is unknown. Here, we characterize a Golgi-derived vesicle, the SEC14L2 compartment, that plays a unique role in facilitating endosome fission through ternary contacts with endosomes and the ER. Localized to the ER-mediated endosome fission site, the phosphatidylinositol transfer protein SEC14L2 promotes phosphatidylinositol 4-phosphate (PtdIns4P) to phosphatidylinositol 3-phosphate (PtdIns3P) conversion before endosome fission. In the absence of SEC14L2, endosome fission is attenuated and more enlarged endosomes arise due to endosomal accumulation of PtdIns4P and reduction in PtdIns3P. Collectively, our data suggest roles of the Golgi network in ER-associated endosome fission and a mechanism involving ER–endosome contacts in the regulation of endosomal phosphoinositide conversion.

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